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Международный журнал экспериментального образования

ISSN 2618–7159
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MOUTH OF LABORATORY ANIMALS FOR ORAL CAVITY PATHOLOGY MODELING

Bukatin M.V. 1 Krivitskaya A.N. 1 Ovchinnikova O.U. 1 Chernikov M.V. 1 Timoshenko A.N. 1
1 The Volgograd State Medical University

The Volgograd State Medical University, Volgograd, e-mail: buspak76@mail.ru

Experimental researches are a component of many scientific works in all areas of medicine and biology. Various kinds of dental pathology are studied on biological models, new dental technologies are developed. Morphological features of a structure dentoalveolar system of the basic objects of medical and biologic experiments (mice, rats, porpoises and hamsters) create some difficulties at modeling in experimental dental. Thus, working out of methods of adequate access to a mouth of small laboratory animals for modeling of dental pathologies is represented an actual problem.

The purpose of the present research was the estimation of adequacy of access to a mouth of laboratory rodents and creation of designs allowing solving a problem of difficulties of this access. The ways described in the literature, are widely used at anatomization of laboratory animals mouth, and consist in introduction in a rodent mouth the structures allowing accurately fix it (metal dilators are directly in mouth, behind the top and bottom cutters). These ways are simple – dilators are “legs” of surgical tweezers. However, these techniques are inefficient in a therapy. Clamps of jaws are the metal designs which are directly in a rodent mouth and, thus, being additional obstacle of access to it. This is the first main lack of available techniques. The second lack is a mechanical influence on the oral cavity mucous membrane, creating additional trauma of soft fabrics. And, at last, the third physical and biochemical lack consists in occurrence of process of electroplating process in an animal mouth. We had been developed an original design, with the account morphofunctional features of rodents’ maxillofacial area which pluses are: an arrangement of clamps of jaws out of an animal oral cavity; clamps are made of a soft material.

Thus, results of our work were technique working out and the design creation, which efficiency in experimental conditions consists in almost unimpeded access in an oral cavity of small laboratory animals.

Now the futility of the method of repeated modeling of dental pathology is proved, due to the fact that the animal in the first complex experiments are killed either immediately or after (within 2-3 days). Consequently it is almost impossible to spend a number of numerous modeling a tooth pathology at a rodent, for revealing of dynamics of this disease and, as consequence, the forecast of efficiency of this or that method of therapy. The design developed by us allows lowering considerably probability of undesirable consequences of modeling on dental system of laboratory rodents.

 The work is submitted to the International Scientific «New technologies, innovation, invention», Maldives, 16-23 March 2011, сame to the editorial office on 10.02.2011


Библиографическая ссылка

Bukatin M.V., Krivitskaya A.N., Ovchinnikova O.U., Chernikov M.V., Timoshenko A.N. MOUTH OF LABORATORY ANIMALS FOR ORAL CAVITY PATHOLOGY MODELING // Международный журнал экспериментального образования. – 2011. – № 2. – С. 9-10;
URL: http://expeducation.ru/ru/article/view?id=4074 (дата обращения: 17.04.2021).

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