Emotional stress is a modern risk factor and complicates the course and prognosis of cardiovascular system diseases, therefore search cardioprotective agents among the anti-stress drugs actions will help to optimize the treatment of cardiovascular disease, and which is currently not only medical but also a social problem of modern medicine.
Pharmacological protection of heart was studied in 340 Wistar rats weighing 150-250 g in experimental model of an emotional stress “The Conflict of afferent stimulations”, simulation of myocardial ischemia in the experimental model pituitrynical coronary spasm (Pituitryn 10 U/kg) and calcium arrhythmia models pathology (Calcium chloride 500 mg/kg), exponentiated by a stress.
Pharmacological protection of heart from damaging operating of an emotional stress and avoidance of development of myocardial dystrophies of a stressful genesis was investigated using anti-stress drugs: following adaptogen Eleutherococcus (0,5 ml/kg), tranquilizer Phenazepam (2,5 mg/kg), nootrop Pyracetam (200 mg/kg) and metabolite of a tryptophan Nicotinamid (50 mg/kg), for which one for the first time in conditions of a pilot model of an emotional stress “The Conflict of afferent stimulations” is rotined availability of cardioprotective properties. Fixed, that capdioprotection with the help these anti-stress drugs realising with help intensifying of developments an own stress-limiting systems of an organism and limitation by them of reactings of stress-realising sistems. It confirms by positive dynamics studied electrophysiological, haemodynamic and metabolic parameters of a functional condition of myocardium in stress and in the pituitrynical coronary spasm and calcium arrhythmia models pathology, exponentiated by a stress.
Availability of cardioprotective properties of studied anti-stress drugs, which one are most expressed for Pyracetam (Pyracetam>Phenazepam>Nicotinamid>Eleutherococcus), allows to recommend them for further targeted application in clinic as cardioprotectors with the medical and preventive purpose in a structure of complex therapy of a pathology of heart of a stressful genesis.
The work is submitted to the International Scientific Conference «Fundamental researches», Jordan (Aqaba), June 8-15, 2014, came to the editorial office оn 26.03.2014
Библиографическая ссылка
Karnaukh E.V., Kirichek L.T. PHARMACOLOGICAL PROTECTION OF HEART BY STRESSPROTECTORS DRUGS IN EXPERIMENTAL CONDITIONS // Международный журнал экспериментального образования. – 2014. – № 6. – С. 13-13;URL: https://expeducation.ru/ru/article/view?id=5830 (дата обращения: 27.09.2024).